Incorrect trafficking route leads to autism
نویسندگان
چکیده
منابع مشابه
Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking
BACKGROUND Pathological accumulation of cholesterol in late endosomes is observed in lysosomal storage diseases such as Niemann-Pick type C. We here analyzed the effects of cholesterol accumulation in NPC cells, or as phenocopied by the drug U18666A, on late endosomes membrane organization and dynamics. METHODOLOGY/PRINCIPAL FINDINGS Cholesterol accumulation did not lead to an increase in the...
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ژورنال
عنوان ژورنال: Brain
سال: 2018
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awy218